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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

Jonathan P. Schneck

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Open access Oct 2026

HIF-1–mediated PPME1 expression promotes breast cancer progression via AKT activation and β-catenin recruitment

Hypoxia-inducible factor 1 (HIF-1) orchestrates the transcriptional regulation of thousands of genes involved in breast cancer (BC) progression. Here, we identified protein phosphatase 2A (PP2A) methylesterase 1 (PPME1) as a critical HIF-1 target gene that drives oncogenic signaling under hypoxic conditions. In BC cell...

Yajing Lyu, Varen Talwar, Yong-Kang Yang et al. · 0 citations
Jul 2026

Nanoscale artificial antigen presenting cells to expand human antigen-specific cytotoxic CD4 T cells for immunotherapy 2258982

The data show that nanoscale aAPCs reliably expand functional antigen-specific CD4 T cells from human PBMCs, providing both mechanistic insight into cytotoxic CD4 biology and a translational foundation for antigen-specific cell immunotherapy.

Si-Sim Kang, Mu-Qing Zhang, Shuyi Li et al. · 0 citations
Open access Jul 2026

Investigating Cytotoxic Function in CD4+ T-cells for Cancer Immunotherapy 2260082

It is shown that aAPCs can drive differentiation of CD4 CTL in vitro and are tunable by cytokine concentration and milieu, particle size, and antigen specificity, which lays the groundwork for further investigation of this non-canonical T-cell subset.

Mara R Lanis, Sujin Kim, Nina M. Nair et al. · 0 citations

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