Author

Joon-Hee Lee

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Open access Aug 2026

Isoflavones with Multifaceted Activities Synergistically Sensitize Pseudomonas aeruginosa to Antibiotics In Vitro and In Vivo

Daidzein and genistein serve as effective adjuncts to conventional antibiotics, exerting multifaceted actions against P. aeruginosa infection, implying a protective effect on host tissues through PPAR-γ activation.

Dan-Dan Li, Tong-Hong Xia, Xin-Ya Zhang et al. · Antibiotics · 0 citations

Open access Aug 2026

A quorum sensing antagonist with dual bacterium- and host-directed anti-pathogenic activity against Pseudomonas aeruginosa

It is demonstrated that Spongosorites sp-derived bisindole alkaloid (R)-6’-debromohamacanthin B (RDB) exerts dual bacterium-directed and host-directed activities, simultaneously attenuating virulence and biofilm formation while reinforcing host defense and controlling pathological inflammation.

Dan-Dan Li, Hui-Yan Li, Wen-Bo Niu et al. · Virulence · 0 citations