Author

Jörg W. Bartsch

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Open access Aug 2026

Small-Molecule Activators of PRMT1: Discovery, SAR Analyses, and Proapoptotic Effects in Pancreatic Cancer Cells

TR-07 is established as the first selective, cell-active PRMT1 activator and underscores the therapeutic promise of this novel class of modulators.

Sepideh Salehipour-Bavarsad, Christian Iking, Jonas Kammertöns et al. · Journal of Medicinal Chemist... · 0 citations

Open access Aug 2026

Deciphering the regulatory role of ADAM8 in the PDAC tumor microenvironment

It is demonstrated that ADAM8 promotes PDAC aggressiveness by enhancing tumor cell proliferation and migration, activating FAK/Src/STAT3 signaling, and driving macrophage and neutrophil recruitment through cytokine regulation.

Kimia Zandieh, L. Cook, Kai Zhao et al. · Cellular Oncology · 0 citations