Author

Jose E. Leon-Rojas

5 papers indexed here

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Review Open access Nov 2026

Clinical Anatomy of the Descending Genicular Artery and Genicular Arterial Network for Embolization and Reconstructive Surgery: A Systematic Review and Evidence Map with Targeted Meta-Analysis

Background/Objectives: The descending genicular artery (DGA) is relevant to genicular artery embolization (GAE), medial femoral condyle and perforator flaps, recipient-vessel selection, and vascular complications around the knee. This review integrated cadaveric, imaging, procedural, reconstructive, and safety evidence...

Alejandro Bruna-Mejías, Valentina Perez-Lira, Diego Santander-Chavez et al. · Diagnostics · 0 citations

Review Open access Oct 2026

Comparative Metabolic Effects of Glibenclamide in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Background: Glibenclamide remains widely used for glycemic control in type 2 diabetes mellitus (T2DM), but its comparative metabolic effects across glycemic, lipid, anthropometric, and cardiometabolic outcomes remain uncertain. We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) co...

J. Valenzuela-Fuenzalida, Antonia Jaña-Barria, Ana Ferrer-Contreras et al. · Life · 0 citations

Review Open access Oct 2026

Anatomical Variations Encountered During the Posterior Approach to the Hip Joint

This narrative review synthesizes variations encountered sequentially during posterior hip exposure and organizes them into superficial, muscular, neurovascular, and osseous domains, providing a practical anatomical roadmap for preoperative planning and intraoperative orientation.

Dimitrios Katsogiannis, G. Triantafyllou, C. Koutserimpas et al. · Journal of Functional Morpho... · 0 citations

Review Open access Oct 2026

Personalized Therapeutic Strategies in Glioblastoma: Bridging Molecular Markers and In Vivo Observations for Targeted Treatment

This review looks at how important molecular drivers, like metabolic changes caused by IDH1/2 mutations, MGMT promoter methylation status, receptor tyrosine kinase signaling involving EGFR and EGFRvIII, and changes in epigenetics seen in H3 K27M, are creating new opportunities in immunotherapy, CAR-T cell therapy, prec...

Joaquin Fiallo Arroyo, Jose E. Leon-Rojas · Biomedicines · 0 citations

Review Open access Sep 2026

Next-Generation Liposomal and Nanoparticle-Based Systems for Glioblastoma: Molecular Targeting Strategies to Overcome the Blood–Brain Barrier

Glioblastoma (GBM) remains one of the most lethal and intractable central nervous system malignancies, characterized by aggressive cellular proliferation, profound hypoxia, and an immunosuppressive microenvironment. The primary pharmacokinetic obstacle for systemic interventions is the blood–brain barrier (BBB), which...

Joaquin Fiallo Arroyo, Bernardo Castellón, Jose E. Leon-Rojas · International Journal of Mol... · 0 citations