Open access
Sep 2026
KDM6A loss enhances oxidative phosphorylation uncovering tissue-level convergent evolution
The tumor suppressor KDM6A/UTX, a histone demethylase and a 2-oxoglutarate-dependent dioxygenase, is frequently lost in many cancer types. We show that KDM6A loss pervasively activates oxidative phosphorylation in several solid tumors, generating a pseudo-hyperoxic environment, opposite from the pseudo-hypoxia observed...
Antonino Alex Cartalemi, D. Rosano, Camilla Ferrari et al.
· EMBO Journal · 0 citations