Open access
Sep 2026
The Drosophila FET ortholog Cabeza is an essential cofactor for ETV4-mediated activation of GGAA microsatellite neoenhancers.
In vivo evidence that non-fused ETS factors cooperate with endogenous FET proteins to drive transcription from silent GGAA repeats is provided, mechanistically validating this regulatory transformation known to operate as an oncogenic mechanism beyond Ewing sarcoma.
Cristina Molnar, Jose Reina, J. Mora et al.
· G3 · 0 citations