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Jose Ruiz-Iglesias

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Review Open access Sep 2026

Beyond Bulk: Cell‐Type‐Resolved Epigenomics as the Path Forward in Alzheimer's Disease Research

Alzheimer's disease (AD) is a complex neurodegenerative disorder in which most risk variants are noncoding and are enriched at gene regulatory regions, implicating epigenetic mechanisms as central mediators of disease pathogenesis. For most of the history of AD epigenetics research, bulk tissue analysis has dominated,...

Lucía Cañizares-Moscato, Jose Ruiz-Iglesias, J. Isoler-Alcaraz et al. · 0 citations

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