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Author

Joseph A. Loo

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Sep 2026

Native Proteomics Reveals Protease-Mediated Hemophore Release by Bacterial Pathogens

Iron is an essential micronutrient for nearly all forms of life, including pathogenic microbes that must acquire it from their host during infection. At the host–pathogen interface, humans restrict microbial access to iron through nutritional immunity, which many pathogens overcome by secreting hemophores that scaven...

Andrew K. Goring, Lindsey R. Lyman, Jordan Ford et al. · 0 citations
Open access Aug 2026

A two-factor authentication mechanism licenses pilins for pilus assembly in gram-positive bacteria.

A "two-factor authentication" mechanism for pilus assembly in gram-positive bacteria is defined: class C sortases first verify pilin identity by forming a membrane-embedded interface that activates the enzyme, then they recognize the LPXTG motif to initiate loading and crosslinking.

Nicole A. Cheung, Reece M. Pawlaczyk, Brendan J. Mahoney et al. · 0 citations

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