Author

Joseph A. Pogliano

3 papers indexed here

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Open access Oct 2026

A bacteriophage split DNA polymerase incorporates a sliding clamp-derived processivity subunit

Viruses that infect bacteria, termed bacteriophages or phages, typically encode their own DNA replication machinery that rapidly generates many copies of the phage genomic DNA in an infected cell. Nucleus-forming phages of the chimallivirus family possess a distinctive repertoire of predicted DNA replication proteins,...

Dwaipayan Basu, Ryan K. Min, Koe Inlow et al. · bioRxiv · 0 citations

Open access Oct 2026

A bifunctional RNase H protein supports DNA replication and transcription in nucleus-forming Chimalliviridae phages

Jumbo bacteriophages of the Chimalliviridae family replicate their genomes within a proteinaceous phage nucleus that spatially segregates viral DNA replication and transcription from translation. While the phage nucleus protects viral DNA from host defenses, it also imposes unique constraints on genome replication and...

Phoolwanti Rani, Niklas Klusch, Shannon M. Barret et al. · bioRxiv · 0 citations

Open access Sep 2026

Rational Design of a Phage Cocktail for Effective Control of Multidrug-Resistant Uropathogenic Escherichia coli from Hospitalized Patients

Background: The emergence of multidrug-resistant (MDR) uropathogenic Escherichia coli (UPEC) poses a significant public health challenge, and alternative treatments are urgently needed. Methods: Here, we identified clinical MDR-UPEC strains AT82 and AT84 collected from hospitalized patients that display extensive antim...

Patiphan Khunti, Panupon Mongkolkarvin, Songphon Buddhasiri et al. · Antibiotics · 0 citations