Author

Joseph Irudayaraj

3 papers indexed here

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Open access Oct 2026

Establishing an in Vitro Model of Astrocyte Activation in Ischemic Traumatic Brain Injury: Therapeutic Synergy of Melatonin and Oxygen Nanobubbles

Secondary injury following ischemic traumatic brain injury (TBI) is heavily driven by neurovascular dysfunction involving endothelial damage, astrocyte reactivity, inflammation, and hypoxic stress, among other contributing pathophysiological processes. Here, we establish a mechanistically informative in vitro ischemi...

J. Igbalaye, Shreyaan Jain, Elisabeth Wenning et al. · ACS Omega · 0 citations

Sep 2026

Parent-of-origin dependent allelic regulation of social behaviors in mice by noncanonically imprinted monoamine synthesis genes.

Monoamine neurotransmitters are central regulators of social behavior, yet it is unknown whether genomic imprinting of genes within their signaling pathways modulate these behaviors. The monoamine synthesis genes tyrosine hydroxylase (Th) and dopa decarboxylase (Ddc) exhibit tissue-specific, noncanonical imprinting in...

E. O'Leary, Rachel L. Eggleston, Daryl D. Meling et al. · Genetics · 0 citations

Open access Aug 2026

Biomimetic hybrid nanoparticles from grape-derived exosome-like particles and liposomes potentiate JQ1-mediated anti-fibrotic effects in hepatic stellate cells.

Activated hepatic stellate cells (HSCs) play a central role in liver fibrosis by promoting extracellular matrix deposition, oxidative stress, and pro-fibrotic signaling. Here, we engineered a membrane-fused hybrid nanoparticle by combining grape-derived exosome-like particles (GELPs) with liposomes to encapsulate JQ1,...

Xiao-Xue Han, Rong Lu, Yi-Jia Zhang et al. · Journal of Pharmacy and Scie... · 0 citations