Author

Joseph Rosenecker

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Open access Jul 2026

Deoxyribonucleotide incorporation reshapes mRNA design beyond canonical ribonucleotide boundaries

These findings identify nucleotide class composition as a previously unrecognized parameter governing IVT-mRNA function and establish hybrid ribonucleotide-deoxyribonucleotide backbone engineering as a versatile strategy to expand the chemical space for next-generation mRNA therapeutics.

Xiaoyan Ding, Riu Liao, G. Bampi et al. · bioRxiv · 0 citations