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Author

Joseph S. Bowness

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Open access Sep 2026

Chromatin structure of the inactive X chromosome revealed by in situ cryo-electron tomography

An innovative approach is applied, direct visualisation of native chromatin structure and its modulation by different factors using cryo-electron tomography, exploiting the inactive X chromosome in differentiating mouse embryonic stem cells as a model system of facultative heterochromatin to illuminate the multiscale o...

Jeongyoon Choi, Dimitrios Bellos, Joseph S. Bowness et al. · 0 citations
Open access Aug 2026

Perturb-seq identifies co-regulated gene programs shaping hematopoietic stem and progenitor cell function

Perturbation-derived co-regulation programs are established as an interpretable framework for linking genetic regulators, cell-biological processes and stem-cell-associated phenotypes by decomposing gene expression data from functional and clinical studies into program activity.

Joseph S. Bowness, Aina Bernal Martínez, Jan Bařinka et al. · 0 citations

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