Open access
Aug 2026
Brain multiomic profiling identifies tau-related transcriptomic dysregulation in Alzheimer’s disease
A hypothetical model of dynamic brain gene expression changes that track with progressive Alzheimer’s disease proteostasis is proposed and found that a beneficial brain biochemical state of higher total tau and lower phospho-Tau is associated with increased levels of synaptic, DNA damage/repair, nucleic acid metabolism...
Stephanie R. Oatman, Zachary S. Quicksall, Xue Wang et al.
· Brain Communications · 0 citations