Many clinically used chemotherapeutics, including doxorubicin, suffer from dose-limiting toxicities, poor biodistribution, and limited control over intracellular activation. To mitigate these challenges, two primary delivery strategies have been widely explored: prodrug design and liposomal encapsulation. Prodrugs ca...
Brooke E. Smith, Jinchao Lou, Miranda A. Phillips et al.· Bioconjugate chemistry· 0 citations
Polyketide synthases (PKS), fatty acid synthases (FAS), and non‐ribosomal peptide synthetases (NRPS) span a variety of protein architectures and catalytic modalities. Common to all these biosynthetic modalities is the centrality of a phosphopantetheinylated carrier protein, which shuttles substrate either inter‐ or int...
Anna-Kay R. West, Tawakalitu A. Afolabi-Balogun, Christian C. Martin et al.· ChemBioChem· 0 citations
An essential role is defined for Bacillus subtilis YumC, a member of a distinct group of bacterial FNRs that resemble thioredoxin reductase, and how the varied roles of redox systems among bacteria depend upon metabolic context is illustrated.
Deniz Akbulut, Marirene Chacón-Arnaude, Dillon P. McBee et al.· bioRxiv· 0 citations
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