We introduce the Cognitive Assessment for Neuropsychological Impairments in Dogs (CANID), a functional evaluation consisting of three cognitive tasks that measure aspects of memory and executive function. CANID can be implemented in a single ~40-min evaluation, was designed for studies of cognitive aging in community...
Stephanie H. Hargrave, Emily Bray, Lorelei R. Switzer et al.· Animal Cognition· 0 citations
A hallmark of chromosomal inversions is that they suppress recombination between haplotypes, allowing inversion haplotypes to persist as single co-inherited units. To determine the extent to which inversions nevertheless permit genetic exchange, we investigated a common 979-kb inversion polymorphism at the human 17q21....
Olivia S. Harringmeyer, Arjun Biddanda, R. McCoy et al.· bioRxiv· 0 citations
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder affecting more than 55 million people worldwide and is characterized by cognitive decline, amyloid-beta (Aβ) plaques, and neurofibrillary tangles. Although transgenic rodent models have advanced understanding of AD, they do not fully replicate the spo...
Abdullatif Alsulami, Marika Bogdani, Evan L. MacLean et al.· npj Dementia· 0 citations
A general theoretical and practical framework for exploiting correlated traits to improve polygenic prediction, provide principled guidance for selecting informative helper traits, and demonstrate how shared genetic and environmental architecture can be leveraged to substantially increase predictive accuracy are establ...
Kaiqian Zhang, Rob Bierman, Joshua M. Akey· bioRxiv· 0 citations
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