Open access
Sep 2026
Dynamic chromatin tethering of MDC1 regulates genome stability
Abstract DNA double-strand breaks (DSBs) are highly cytotoxic DNA lesions because they disrupt the connectivity of the DNA strand. Homologous recombination (HR) is a high-fidelity DSB repair pathway that copies the sequence spanning the break from a homologous template, but how DNA ends are held together during HR rema...
Joshua R. Heyza, Mariia Mikhova, Cody Phillips et al.
· Nucleic Acids Research · 0 citations