Author

Joshua T. Dearborn

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Open access Aug 2026

In vivo optical clearing of the mouse brain

Light microscopy is one of the most powerful tools for understanding living systems, but the opacity of tissue prevents visualization of all but superficial layers. Several methods to clarify tissue have been developed, but most require fixed specimens. To address the challenge of improving resolution in functioning ne...

Maiko Kume, Ning-Dong Kang, Alejandro Akrouh et al. · bioRxiv · 0 citations

Open access Jul 2026

Chronic oral cannabidiol delays seizure onset and reduces seizure burden in a mouse model of CLN2 disease

It is shown that chronic treatment with cannabidiol confers significant anti-seizure benefit to the mouse model of CLN2 disease, and that it does not appear to do so by altering the inflammatory and neuroimmune markers traditionally used to track CLN2 disease progression.

Joshua T. Dearborn, Keigo Takahashi, N. Rensing et al. · PLoS ONE · 0 citations