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Sponsored Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt

Author

József Simon

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2 papers indexed here

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Aug 2026

Should I Stay or Should I Go-Leveraging an Overlooked Feature of Click-to-Release Chemistry for Affinity Labeling.

Click-to-release (C2R) chemistry is widely used for controlled payload liberation, yet the reactivity of its transient intermediates has remained largely unexplored. Here we show that an intermediate formed during the reaction of trans-cyclooctene (TCO)-appended protein-targeting ligands with release tetrazines (rTzs),...

Dóra Kern, K. Németh, T. Imre et al. · 2 citations
Open access Sep 2026

Fragment-Based Covalent Targeting of Lysines at the Allosteric Latch Site of SHP2

Covalent mechanism of action is a powerful way to modulate challenging drug targets. Here, we present a streamlined workflow that combines covalent fragment screening (electrophile first approach) and ligand-first strategy to identify covalent inhibitors targeting lysine residues in the allosteric latch site of SHP2...

Vincenzo di Lorenzo, Noémi Csorba, Renáta Szabó et al. · 0 citations

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