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Juan C. Valdez-Lopez

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Open access Aug 2026

Retinal degeneration in a mouse model of CRB1 disease rescued by the photoreceptor-specific CRB1-B isoform

It is found that restoring CRB1-B to photoreceptors prevents degeneration and completely rescues visual function, despite the absence of other isoforms, and suggests that exploring disease gene isoform diversity offers an untapped opportunity to devise novel therapeutics.

Ekta Dembla, Juan C. Valdez-Lopez, Christopher Kozlowski et al. · 0 citations

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