Oct 2026
ED-71 ameliorates oxeiptosis-associated signaling in BMSCs under diabetic osteoporosis by alleviating PKM2-associated metabolic dysregulation and mitochondrial dysfunction.
ED-71 may alleviate mouse DOP by reducing PKM2 expression to correct metabolic reprogramming and mitochondrial dysfunction, thereby suppressing oxeiptosis and restoring HG-treated BMSCs' osteogenic potential, offering a novel mechanistic foundation for its therapeutic application.
R. Yuan, Ya-Jun Cui, Jun Sun et al.
· Cellular Signalling · 0 citations