Author

Juan Lin

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Review Open access Sep 2026

Randomised treatment of acute pancreatitis with infliximab: protocol for a double-blind, placebo-controlled, multi-centre, adaptive, phase 2 superiority trial (RAPID-I)

Abstract Introduction Acute pancreatitis (AP) is an increasingly common cause of substantial morbidity and risk of mortality without licensed specific drug therapy. Because tumour necrosis factor α (TNF-α) contributes to AP, anti-TNF therapy may improve outcome from AP. This trial aims to test the efficacy, safety, cos...

Juan Lin, M. Smyth, C. Spowart et al. · BMJ Open · 0 citations

Open access Sep 2026

Development and external evaluation of an interpretable machine-learning model for early prediction of organ failure in higher-risk acute pancreatitis patients: A multicentre cohort study

Organ failure (OF) is the most important determinant of prognosis in acute pancreatitis (AP) and its duration defines disease severity. Early identification of individuals at high risk of developing OF is crucial. We aimed to develop machine-learning models, benchmarked against a feedforward multilayer-perceptron (MLP)...

Di Wu, W. Cai, Chun-Mei Chen et al. · PLOS Digital Health · 0 citations