Author

Juan Wang

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Review Open access Sep 2026

Chimeric antigen receptor (CAR)-T cell therapy for solid tumors in pediatric patients: current breakthroughs, dilemmas, and strategies

Recent advances, persistent challenges, and emerging strategies for CAR-T cell therapy in pediatric solid tumors are summarized and rational combination strategies involving CAR-T cell therapy with chemotherapy, radiotherapy, and immune checkpoint inhibitors aimed at improving therapeutic efficacy and safety are discus...

Yu-Miao Mai, Zi-Wen Wang, Juan Wang et al. · Experimental Hematology & On... · 0 citations

Open access Sep 2026

GATA3-driven CDC20 activation facilitates tumor growth and metastasis through suppressing Bax/Bcl-2 ratio and boosting EMT process in neuroblastoma.

Neuroblastoma (NB) is a heterogeneous pediatric malignancy in which many high-risk tumors lack MYCN amplification, necessitating the identification of alternative molecular drivers. Here, integrative transcriptomic analyses of MYCN-nonamplified NB cohorts identified cell division cycle 20 (CDC20) as a candidate associa...

Xiao-Na Fang, Ying-Xia Lan, Meng-Zhen Li et al. · Journal of Biological Chemis... · 0 citations