Author

Juan Yuan

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Review Open access Oct 2026

Spatial heterogeneity in glioblastoma: linking single-cell and spatial multi-omics to vaccine immunotherapy

Glioblastoma (GBM) remains the most lethal primary brain tumor, with survival still limited despite advances in multimodal treatment. The tumor’s profound heterogeneity--across patients, within individual tumors, and over time--has frustrated every class of therapeutic intervention. Recent developments in single-cell a...

Juan Yuan, Yong Liu · Frontiers in Immunology · 0 citations