RUNX3 interaction with ATRAP regulates STZ-induced T1DN injury through NLRP3 inflammasome.
OBJECTIVE This study investigated whether RUNX3 regulates renal injury in diabetic nephropathy (DN) via ATRAP-dependent NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome inhibition. METHODS Type 1 diabetic nephropathy (T1DN) was induced in wild-type and kidney-specific Runx3 conditional knockout...