Judy J. Yoo

Alternative splicing plasticity of the neurexin family of synaptic adhesion molecules in human sensory neurons

Plasticity within somatosensory circuits enables adaptations to environmental changes, however these can become maladaptive following injury and lead to chronic pain states. Presynaptic neurexins (Nrxns) are key organizers of synapse function that bind to a wide variety of postsynaptic proteins in a splice-isoform depe...