Author

Juexin Wang

5 papers indexed here

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#diffusion models Open access Oct 2026

CellDiffusion: Enhancing scRNA-seq data integration with accurate inference of cell-cell association

Integrating single-cell transcriptomic datasets across laboratories, conditions, and technologies remains challenging because of cell type–specific batch effects and heterogeneous biological compositions. Current methods often fail to separate genuine biological variation from technical noise, misaligning distinct cell...

Yu-Chen Liu, Zi-Ying Huang, S. Lu et al. · Science Advances · 0 citations

Open access Sep 2026

Semi-metric optimal transport enables robust spatial multi-omics integration

Integrating heterogeneous spatial multi-omics data to uncover underlying biological and pathological mechanisms remains a major challenge, while existing approaches generally lack mathematically justified distances for comparing complex spatial tissues. We introduce Spatial Optimal Transport (SpaOT), a spatial multi-om...

Shuang Wang, Yi-Kun Bai, R. M. Ferreira et al. · Research Square · 0 citations

Open access Oct 2026

Functional characterization and pharmacochaperone rescue of a novel SLC6A1 variant associated with developmental epileptic encephalopathies

Mutations in SLC6A1 , encoding the γ-aminobutyric acid (GABA) transporter 1 (GAT-1), are associated with a spectrum of neurodevelopmental disorders, including epilepsy syndromes, intellectual disability (ID), and autism. An important question is whether the impact of these mutations can be predicted at scale usin...

Ziang Song, Melissa B. DeLeeuw, Despoina Mandelenaki et al. · Scientific Reports · 0 citations

Case report Open access Aug 2026

4-Phenylbutyrate Plus Wildtype GAT-1 Augmentation: A Dual Therapy to Rescue SLC6A1 Variant-Associated Developmental and Epileptic Encephalopathy

These findings support a two-pronged precision-medicine framework for SLC6A1-related DEEs in which PBA increased the transporter function augmented by genetic approaches, and pharmacochaperones (PBA, TUDCA) restored GABA uptake for the mutant transporters.

A. Delahanty, K. James, E. Carter et al. · Genes · 0 citations

Open access Jul 2026

4-Phenylbutyrate Rescue in GABRA1 Variants Associated with Developmental Epileptic Encephalopathies: From Cell and Mouse Models to Humans

This study indicates that PBA is a promising treatment option for DEEs associated with GABRA1 mutations and proposes that PBA holds promise as a common medicine for multiple genetic neurologic disorders that share the proteostasis pathology with a broad clinical application in DEEs.

Ziang Song, Kirill Zavalin, W. Shen et al. · Cells · 0 citations