Julia C. Reisenbauer

Designing enzymes for new-to-nature chemistry and non-natural substrates with AlphaProtein Novo

Reframing enzyme function prediction as conditional generation

Fluxion is presented, a generative deep learning framework that learns enzyme-dependent regioselectivity across cytochrome P450 enzymes by modeling dynamic electron flow trajectories across the enzyme’s catalytic residues by combining both synthetic chemistry and biochemical datasets with protein language model represe...

Protein engineering: status report

Protein engineering appears to be entering a golden age, defined by a rapidly accelerating pace of progress, even as significant challenges in design, screening, and real-world application remain.