Author

Julia Tcw

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Open access Aug 2026

APOE3 and APOE4 human astrocytes differentially modulate Alzheimer’s disease pathology and microglial responses in chimeric mice

A chimeric model of AD is generated by transplanting isogenic APOE3 or APOE4 human induced pluripotent stem cell-derived astrocyte progenitors into neonatal AD mice and highlighting a role for human astrocytes and APOE-dependent astrocyte functions in modulating AD-related pathology.

Joan Cruz-Sesé, Marta Mirón-Alcala, Maria Alfonso-Triguero et al. · Cell Reports · 0 citations

Sep 2026

APOE4 astrocytes call the shots on neuronal α-synuclein pathology.

In this issue of Cell Stem Cell, Mesentier-Louro et al. use a multi-cellular integrated brain (miBrain) system to uncover mechanisms underlying the accumulation of neuronal α-synuclein (α-Syn) inclusions in APOE4 carriers.1 Their results suggest that APOE4 increases cholesterol levels and impairs lysosomal function in...

Nicole R. West, Julia Tcw · Cell Stem Cell · 0 citations