Author

Julian D. Langer

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Open access Sep 2026

Mouse Neural Organoids Model the Mature In Vivo Synaptic Proteome

Neural organoids represent a promising approach for modelling neural circuits and neurological disease, yet their utility depends on whether they can recapitulate the molecular complexity of mature brain synapses. Here, we optimized a protocol to generate mature forebrain organoids from mouse embryonic stem cells and u...

Stefano L. Giandomenico, Marc van Oostrum, Quinn Waselenchuk et al. · bioRxiv · 0 citations

Open access Aug 2026

Characterization of Full‐Length Antibody Complexes Through HDX‐Mass Spectrometry Coupled With NMR Spectroscopy: New Insight Into Avelumab/PD‐L1 Interaction

ABSTRACT Recombinant biomacromolecules have significantly transformed pharmaceuticals, in particular monoclonal antibodies (mAbs) that target key areas in oncology, immunology, inflammation, and neurodegenerative diseases. Developing biotherapeutics requires a detailed understanding of their biological properties. This...

Francesca Sacco, F. Baroni, A. Capolupo et al. · Angewandte Chemie · 0 citations