Author

Julian Herold

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Open access Sep 2026

Conditional Generation and Inpainting of Non-Coding RNA Sequences with Masked Discrete Diffusion

Designing functional non-coding RNA (ncRNA) is fundamental to synthetic biology and RNA therapeutics, yet generative modelling for ncRNA has received far less attention than protein design. We present RNA-MDLM, a framework that extends Masked Discrete Language Models (MDLM) to the conditional generation and inpainting...

Utkarsh Upadhyay, Chuan-Kai Dai, Julian Herold et al. · bioRxiv · 0 citations

Open access Sep 2026

NucleicBERT interprets RNA sequence space through self-supervised language modelling

NucleicBERT is developed, a self-supervised masked-language model that learns contextual representations from single sequences without evolutionary information that advances RNA structure prediction and informs how large language models encode biological information.

Utkarsh Upadhyay, Julian Herold, Markus Götz et al. · Nature Machine Intelligence · 1 citation