Julian Lava

Light-Mediated Desulfurization of Peptides in Multi-Well Format for Combinatorial Library Synthesis

Native chemical ligation (NCL) combined with post-ligation desulfurization is a powerful strategy for the chemical joining of unprotected peptide segments to form larger polypeptides or to synthesize head-to-tail cyclized peptides. However, a simple, robust, and safe desulfurization protocol suitable for high-throughpu...