Author

Julie G. Burel

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Open access Sep 2026

A high-resolution blood immune cell doublet atlas via imaging spectral cytometry

Circulating cell-cell complexes (doublets) provide critical insights into in vivo immune interactions. Here, we leverage high-dimensional imaging spectral cytometry to systematically map the landscape of immune doublets in human peripheral blood. By integrating morphometric imaging features with a 22-color spectral pan...

Cheryl Kim, Denise Hinz, Aaron Middlebrook et al. · bioRxiv · 0 citations

Open access Aug 2026

Enrichment of CD4−CD8− cytotoxic Vδ1/3 T cells in pulmonary tuberculosis disease

This study used single-cell RNA sequencing to provide a high-resolution characterization of CD4−CD8− γδ T cells in peripheral blood across healthy Mtb-(non-)sensitized and TB disease pre-/post-treatment cohorts and found an activated and cytotoxic gene signature in γδ T cells of TB disease compared with both healthy co...

Kendall Kearns, R. Tippalagama, Ashu Chawla et al. · iScience · 0 citations

Jul 2026

Single-Cell Transcriptomic Analysis Of Imaging-Sorted Circulating Immune Cell Doublets In Active Tuberculosis 2309416

Using the recently commercialized FACSDiscoverTM S8 spectral imaging cell sorter, image-based cell sorting provides unprecedented granularity in the study of immune doublets and enrichment for biological doublets over technical artifacts.

Ning-Xin Kang, Cheryl Kim, Thomas J. Scriba et al. · Journal of Immunology · 0 citations