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Julie Smeyers

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Review Open access Sep 2026

Minding the gates: dual cell-autonomous and non-cell-autonomous mechanisms of TBK1 in ALS/FTD

The multifaceted role of TBK1 as a master regulator of proteostasis and inflammatory pathways is discussed, its critical role in maintaining microglial homeostasis is highlighted, and how these convergent functions inform therapeutic strategies for ALS/FTD is explored.

Julie Smeyers, Daniel A. Mordes · 0 citations

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