Review
Open access
Sep 2026
Minding the gates: dual cell-autonomous and non-cell-autonomous mechanisms of TBK1 in ALS/FTD
The multifaceted role of TBK1 as a master regulator of proteostasis and inflammatory pathways is discussed, its critical role in maintaining microglial homeostasis is highlighted, and how these convergent functions inform therapeutic strategies for ALS/FTD is explored.
Julie Smeyers, Daniel A. Mordes
· Frontiers in Neuroscience · 0 citations