Targeting Mitochondrial-Endoplasmic Reticulum Contact Sites (MAMs) Bioenergetics to Prevent Myocardial No-Reflow: A Non-Equilibrium Thermodynamic Framework
Despite high procedural success rates in primary percutaneous coronary intervention (PCI), acute myocardial infarction remains heavily burdened by the « no-reflow » phenomenon and progressive microvascular obstruction [1, 2]. Current pharmacological strategies fail to address the underlying biophysical failure occurrin...