Synthesis of mannosides as potential inhibitors of PIMs biosynthesis in mycobacteria.
The discovery of new therapeutic targets for combating tuberculosis has become crucial due to the alarming increase in multi-drug resistant strains. The acyltransferase PatA, involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIMs), key components of the mycobacterial cell wall, has recently been sho...