Author

Julien Mignon

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Open access Aug 2026

CLEC-1 promotes early IFN response in cDC1s and favors immune dysregulation during sepsis in mice

It is demonstrated that blocking CLEC-1 using an anti-human CLEC-1 monoclonal antibody mitigates hyperinflammation in CLEC-1 humanized mice and suggests its potential as an immunotherapeutic target.

T. Ogor, Esther Porée, J. Saenz et al. · iScience · 0 citations

Open access Aug 2026

Sequence‐encoded determinants drive distinct early aggregation pathways and different structural outcomes in PNT1 fibrils across Henipavirus members

Findings indicate that the sequence context beyond a conserved amyloidogenic core governs the aggregation landscape of Henipavirus P, V, and W proteins, shedding light on the molecular grammar underlying viral protein fibrillation with potential implications for viral pathogenicity.

Harshita Sawdekar, Julien Mignon, Frank Gondelaud et al. · Protein Science · 0 citations