Author

Julien Oury

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Open access Sep 2026

Engineering suppressor tRNAs for effective treatment of Duchenne muscular dystrophy

Duchenne muscular dystrophy (DMD) is a fatal disorder caused by loss of dystrophin, a protein essential for muscle cell integrity. To date, no therapeutic has restored full-length dystrophin. Suppressor transfer RNAs (sup-tRNAs) have the potential to treat the ∼15% of patients with DMD and nonsense mutations. We have e...

Julien Oury, Ying-Hsin Chen, Sean Mcfarland et al. · Science Advances · 0 citations