Targeted metabolic phenotyping by liquid chromatography–tandem mass spectrometry (LC-MS/MS) relies on a fragmented toolchain of proprietary vendor formats, manual integration steps, and ad hoc quality-control (QC) scripts, introducing user- and laboratory-level variation that undermines reproducibility and confounds cr...
Harrison Szemray, Vimalnath Nambiar, Dana Hicks et al.· Metabolomics· 0 citations
Systematic literature reviews are widely acknowledged to be at the top of most evidence hierarchies but are very time-consuming and labour-intensive. The advent of artificial intelligence (AI) offers possibilities to accelerate the review process. We propose a systematic literature review protocol that incorporates A...
Maartje Cox, Javier Osorio Mosquera, Shaimaa Khandaker et al.· Phenomics· 0 citations
Autism spectrum disorder (ASD) has been associated with gut microbiome and metabolic alterations, but reported biomarkers are inconsistent and often inadequately account for family and shared environment. We analysed 620 children, including 334 with ASD and 286 neurotypical siblings, with a median age of 6.0 years (IQR...
Ashley G. Bell, Kiana A. West, Gary Frost et al.· bioRxiv· 0 citations
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