Author

Jun Chen

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Open access Aug 2026

Reversing KDM6A phosphorylation-driven epigenetic suppression restores pyroptosis and synergizes with anti-PD-1 therapy in HNSCC

KDM6A phosphorylation is identified as a druggable epigenetic-immune checkpoint and mRNA-based modulation of enzyme post-translational status as a transformative paradigm to potentiate ICB in HNSCC is established.

Yi-Kang Ji, Xin-Ran Zhao, Cheng Hu et al. · Cell Death & Disease · 0 citations