Author

Jun Chen

h-index 2 View on Semantic Scholar

We have 3 of 7 papers

We haven’t gathered this author’s papers yet. Follow them and we’ll fetch their work.

Not the right person? Other researchers publish under this name.

Open access Aug 2026

KDM6A suppresses proliferation and epithelial-mesenchymal transition in prostate cancer cells.

BACKGROUND AND OBJECTIVE Prostate cancer is one of the most common male malignancies worldwide. KDM6A, a histone H3K27 demethylase, has been implicated in various cancers; however, its specific functions in prostate cancer remain controversial. This study aimed to investigate the regulatory role of KDM6A in castration-...

Yi-Xiu Ni, Yi-Jia Lin, Wan-Kun Wang et al. · Urologic oncology · 0 citations

Open access Sep 2026

Follistatin drives AR-independent prostate cancer through BMP signaling inactivation and microenvironmental remodeling.

Resistance to androgen receptor (AR)-targeted therapies remains a major clinical challenge in advanced prostate cancer. Here we identify follistatin (FST), TGFβ superfamily antagonist, as a key driver of AR-independence and treatment resistance. During anti-AR therapy, cancer cells progressively lose the positive feedb...

Xiao-Xian Shi, Zu-Yan Fan, Min Qu et al. · Proceedings of the National... · 0 citations

Open access Aug 2026

Reprogramming PD-L1 endosomal recycling and lysosomal degradation via engineered exosome-based nanocomposites overcomes immune resistance in lung cancer brain metastasis

A pH-responsive nanocomposite engineered by functionalizing brain-metastatic tumor cell-derived exosomes with RGD peptides for targeted co-delivery of verteporfin and αPD-L1 successfully remodels the intracranial immunosuppressive microenvironment and triggers potent systemic anti-tumor immunity.

Xiujuan Hong, Xiao-Qi Wang, Wan-Kun Wang et al. · Materials Today Bio · 0 citations