Oxymatrine suppresses stiffness-induced epithelial-mesenchymal transition in breast cancer by targeting the PKN3-GRAF1 signaling axis.
PURPOSE Increased extracellular matrix stiffness is a critical driver of epithelial-mesenchymal transition (EMT) and metastatic progression in breast cancer; however, effective pharmacological strategies targeting intracellular mechanotransduction remain limited. This study investigated whether oxymatrine, a bioactive...