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Jun-Hak Lee

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Review Open access Sep 2026

AMPK-Directed Therapeutics for MASLD: Mechanistic Rationale, Activator Classes, and Clinical Translation

Metabolic-associated steatotic liver disease (MASLD) affects an estimated 25–30% of the global adult population and represents a leading cause of liver-related morbidity. However, approved pharmacological therapies remain strictly limited. AMP-activated protein kinase (AMPK), a highly conserved heterotrimeric serine/th...

Reeju Amatya, Ye-Nan Ji, Jun-Hak Lee et al. · 0 citations

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