Author

Jun-Hong Han

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Review Aug 2026

Beyond senescence entry: individual-cell fates, population outcomes and therapeutic implications in ageing and disease.

Cellular senescence is a stress-response program characterized by durable proliferative arrest, but senescence entry does not determine a single biological outcome. Confusion between the fate of an individual cell and the behavior of a senescent-cell population has obscured interpretation across development, ageing and...

Guosong Wang, Yang Meng, Jun-Hong Han · Ageing Research Reviews · 0 citations

Review Open access Aug 2026

Histone modifications: mechanisms, metabolic regulation, and therapeutic targeting in cancer

This review comprehensively summarizes the multifaceted roles of major histone modifications, including acetylation, methylation, ubiquitination, phosphorylation, and emerging metabolism-linked acylations, in governing critical DNA-templated processes such as replication, transcription, and the DNA damage response.

Ling-Li Wang, Shi-Ying Li, Xiao-Yan Hu et al. · Precision Clinical Medicine · 0 citations

Open access Jul 2026

Targeting HASPIN-mediated H3T3 phosphorylation disrupts an epigenetic-kinesin axis to suppress colorectal cancer mitotic progression.

Chemoresistance remains a major barrier in colorectal cancer (CRC) therapy. Through epigenetic compound screening in patient-derived organoids (PDOs), we identified CX6258.HCl as a potent growth inhibitor. Treatment with CX6258.HCl significantly inhibited cell mitosis and induced apoptosis in CRC cell lines. Mechanisti...

Tong Wu, Yaguang Zhang, Sicheng Liu et al. · Molecular Cancer · 0 citations