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Author

Jun-Ji Zhu

2 papers indexed here

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Open access Sep 2026

Nsp3 Ubl1-orchestrated dephosphorylation of N protein promotes coronaviral subgenomic RNA synthesis

The coronavirus nucleocapsid (N) protein is indispensable for the viral lifecycle as part of the viral Replication-Transcription Complex together with Nsp3. Recent research demonstrated that phosphorylation of N by several host kinases intricately regulates its functions during infection. However, the mechanisms that c...

Jun-Ji Zhu, C. Chiang, Michaela U. Gack · 0 citations
Open access Aug 2026

Virus-induced deconjugation of ISG15 dysregulates innate immunity and cellular metabolism.

Interferon-stimulated gene 15 (ISG15) encodes a ubiquitin-like protein that regulates diverse cellular responses, including antiviral immunity, through its conjugation to proteins in a process known as ISGylation. Several pathogens, including SARS-CoV-2, subvert ISGylation by encoding deISGylating enzymes. However, the...

Jun-Ji Zhu, Guan-Qun Liu, Jie-Lin Xu et al. · 0 citations

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