Author

Jun-Jie Du

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Open access Sep 2026

Mycn facilitates hematopoietic stem and progenitor cell generation from endothelial cells by inhibiting adhesion signaling.

Hematopoietic stem and progenitor cells (HSPCs) arise from hemogenic endothelial cells (HECs) via the endothelial-to-hematopoietic transition (EHT). As a signature gene of hematopoietic stem cell-primed HECs, Mycn is highly expressed in these cells alongside its paralog, Myc. However, their roles and underlying mechani...

Chi Wang, Zhe Chen, Mei-Lin Jiang et al. · Cell Reports · 0 citations

Open access Aug 2026

RACK1 maintains mouse hematopoietic stem cells by directly binding to and stabilizing LDB1

Single-cell RNA sequencing indicates that adulthood Rack1 deletion in type I interferon-I-responsive cells leads to aberrant lineage-geneset-scores of transcriptional HSCs and the emergence of stressed HSCs, and Mechanistically, RACK1 prevents HSC loss through maintaining the protein level of LDB1.

L. Deng, Jun-Jie Du, Zhe Xu et al. · Cell Death & Disease · 0 citations