VEXAS Syndrome: A Comprehensive Review for Dermatologists Part 1: Epidemiology, Pathophysiology, and Clinical Presentations.
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) syndrome is a newly recognized, ubiquitin-activating enzyme E1 (UBA1)-mediated autoinflammatory disorder characterized by treatment-refractory systemic inflammation and diverse cutaneous findings. Dermatologists are uniquely positioned to facilitate early...