Copper-Mediated Valence Tautomerism Enables α -C(sp3)–H Alkylation of 1,3-Dicarbonyl Compounds and Tryptophans via Photocatalysis
Carbonyl α-C(sp3)–H functionalization is a key approach to access functionalized pharmaceuticals, agrochemicals, and bioactive peptides. Conventional two-electron enol tautomerization strategies for this transformation often suffer from harsh reaction conditions and limited substrate tolerance. While valence tautomer...