RIVER: Evidence-guided multi-agent retrieval for enzyme--reaction discovery
Enzyme function annotation and the identification of candidate enzymes for a given reaction are essential steps in connecting genomic information to biochemical reaction networks. However, existing methods rely on sequence or structural similarity or on training with known enzyme--reaction pairs, making it difficult to...
Yi-Fan Chang, Yun-Ze Li, Fei-Fei Jiang et al.
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