Jun Wang

Development of Enterovirus D68 3C Protease Inhibitors with In Vivo Efficacy in a Neurological Infection Model

Enterovirus D68 (EV-D68) is a non-polio enterovirus that primarily causes respiratory illness but can also lead to severe disease, including acute flaccid myelitis. No approved vaccine or antiviral is available. Here, we report the rational design and structure−property optimization of dipeptidyl EV-D68 3C protease (...

CAMKV kinase drives neuroblastoma growth and acts as a novel therapeutic target.

Targeting Picornavirus Nonstructural 2C Protein: Structure, Function, and Antiviral Discovery

Current evidence supports 2C as a tractable yet still underexploited antiviral target for medically important picornaviruses.

Development of Covalent Inhibitors of Chikungunya Virus nsP2 Cysteine Protease Enabled by Direct-to-Biology Synthesis and Screening

A rapid drug development platform that integrates covalent docking with direct-to-biology (D2B) synthesis and screening to identify nsP2 inhibitors is presented, which establish a streamlined strategy for covalent inhibitor development and provide promising leads for CHIKV antiviral development.

SARS-CoV-2 Papain-Like Protease: Drug Design, Assay Development, and Drug Resistance.

This Account summarizes the group's effort to convert PLpro from a challenging target into a tractable antiviral drug-discovery platform and illustrates how integrated assay development, structural biology, medicinal chemistry, pharmacology, virology, and resistance analysis can transform a challenging viral deubiquiti...