Author

Jun Wang

3 papers indexed here

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Oct 2026

CircNFIB attenuates hypoxia/reoxygenation-induced ferroptosis in AC16 cardiomyocytes with involvement of the miR-338-3p/GPX4 pathway.

Cardiomyocyte ferroptosis contributes to myocardial ischemia/reperfusion injury, but the upstream noncoding RNA mechanisms remain incompletely defined. This study examined whether nuclear factor I B-derived circular RNA (circNFIB) regulates hypoxia/reoxygenation (H/R)-induced ferroptosis in human ventricular cardiomyoc...

Rong Huang, Jun Wang, Jun-Chen He et al. · Biochemical Pharmacology · 0 citations

Open access Oct 2026

Time-Stable Ferroptosis-Related Candidate Genes in Myocardial Ischemia/Reperfusion Injury Identified by Multi-Time-Point Transcriptomic Analysis: Prioritization of NCF2 Through Public Datasets and AC16 Cell Validation

NCF2 showed the most consistent support across datasets, sample types and AC16 H/R experiments, suggesting it as a prioritized candidate linking ferroptosis-related oxidative stress and myeloid immune activation.

Rong Huang, Jun Wang, Jun-Chen He et al. · Journal of Inflammation Rese... · 0 citations

Sep 2026

Astragaloside IV attenuates cerebral ischemia-reperfusion injury by suppressing PERK/eIF2α/ATF4-mediated endoplasmic reticulum stress through activation of the SHH signaling pathway.

BACKGROUND Cerebral ischemia-reperfusion injury (CIRI) triggers endoplasmic reticulum stress (ERS), a key pathological driver of neuronal apoptosis and neurological impairment. While the neuroprotective effects of astragaloside IV (AS-IV) are well-documented, the precise regulatory bridge between the Sonic Hedgehog (SH...

Ping-Bo Wei, Yang-Yun Han, Jun Wang et al. · Brain Research · 0 citations